NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10), is an accessory subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), which is the first and largest enzyme of the mitochondrial respiratory electron transport chain. NDUFA10 is believed not to be directly involved in catalysis but is required for proper complex I assembly or stability. Its principal function is part of the multi-protein machinery that transfers electrons from NADH to ubiquinone, coupled to proton translocation, driving ATP synthesis by oxidative phosphorylation. Mutations in NDUFA10 have been implicated in severe mitochondrial disorders, including Leigh syndrome and other forms of mitochondrial complex I deficiency.

Other names

NDUFA10NADH:ubiquinone oxidoreductase subunit A10CI-42kDCI-42kComplex I-42kDNADH-ubiquinone oxidoreductase 42 kDa subunitcomplex I 42kDa subunitCI-42KDMC1DN22

For the overall complex: facilitation of electron transfer from NADH to ubiquinone, contributing to oxidative phosphorylation; NDUFA10 itself believed to be an accessory subunit not directly involved in catalysis